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周宏钰
作者:  来源:  上传:admin  发布时间:2016-03-13 10:18:38  浏览次数:6384

周宏钰,男,理学博士,教授,博士生导师,“齐鲁青年学者”特聘教授

E-mail:hyzhou001@gmail.com

通信地址:济南市山大南路27号山东大学环境科学与工程学院 ,邮编:250100

学习经历:

2000.9-2004.7  山东大学 应用化学专业,理学学士;

2004.9-2009.6  山东大学 药物化学专业,理学博士;

2007.6-2009.5  美国St. Jude 儿童研究医院 联合培养博士.


工作简历:

2009.9-2012.4   美国St. Jude 儿童研究医院,博士后;

2012.4-2016.2   美国艾默里大学,博士后;

2016.3-至今     山东大学环境科学与工程学院,教授,博士生导师.


学术服务:

Advanced Functional Materials,Small,Current Medicinal Chemistry,International Journal of Nanomedicine,ACS Combinatorial Science,Biomaterials,Materials Research Express等学术期刊的审稿人.


主要研究领域:

研究领域为纳米材料的环境效应,研究兴趣包括:1)纳米颗粒组合化合物库的快速高通量构建及其生物效应调控;2)计算机化学辅助结合纳米材料化合物库进行纳米毒理学研究;3)应用于环境领域的新型纳米探针研发。


以第一作者或通讯作者在J. Am. Chem.Soc., Nano Lett., ACS Nano., Chem. Eur. J.等知名国际刊物上发表学术论文35篇, 科技著作章节2篇,申请7项中国专利。截至2016年2月,所发表文章共被他引752次(源自Web of Science查询)。


代表论文:

1)Jiao PF,  Otto M, Geng QH, Li CC, Li FM, Butch E.R., Snyder S.E., Zhou HY*, Yan B* Enhancing Both CT Imaging and Natural Killer Cell-Mediated Cancer Cell Killing by a GD2-Targeting Nanoconstruct, J. Mater. Chem. B 2016, 4, 513-520. (IF 4.72)

2)Zhou HY, Qian WP, Uckun F. M, Wang LY, Wang A. Y, Chen HY, Kooby D, Yu Q, Lipowska M, Staley C. A, Mao H, Yang L* IGF1 Receptor Targeted Theranostic Nanoparticles for Targeted and Image-guided Therapy of Pancreatic Cancer. ACS Nano, 2015, 9, 7976–7991.(IF 12.881)

3)Zhou HY, Zhang Y, Su G, Yan B.*Enhancing Radiation-Induced Cell Killing by a Cancer-Targeting Gold nanoconstruct with Doxorubicin Payload. RSC Adv. 2013, 3, 21596-21603. (IF 3.70)

4)Zhou HY, Su GX, Jiao PF, Yan B.* Accelerating multifunctionalization of theranostic nanoparticles using multicomponent reaction. Chem. Eur. J. 2012, 18, 5501-5505. (IF 5.69)

5)Zhou HY, Jiao PF, Yang L, Li X, Yan B.* Enhancing Cell Recognition by Scrutinizing Cell Surfaces with a Nanoparticle Array. J. Am. Chem. Soc. 2011, 133, 680–682. (IF 11.44)

6)Zhou HY, Li X, Lemoff A, Zhang B, Yan B.* Structural Confirmation and Quantification of Individual Ligands from the Surface of Multi-Functionalized Gold Nanoparticles. Analyst, 2010, 135, 1210-1213. (IF 3.90)

7)Zhou HY, Zhang W, Yan B.* Use Cyclohexylcyanide and Methyl 2-Isocyanoacetate as Convertibel Isocyanides for Microwave-Assisted Fluorous Synthesis of 1,4-Benzodiazepine-2,5-dione Library. J Comb Chem 2010, 12, 206-214.(IF 3.40)

8)Du FF#, Zhou HY# (Co-first author), Chen LQ, Zhang B, Yan B.* Structure Elucidation of Nanoparticle-Bound Organic Molecules By 1H NMR. TRAC-Trends Anal Chem2009, 28, 88-95.(IF 6.61)

9)Zhou HY, Liu AF, Li XF, Ma XF, Feng W, Zhang W, Yan B.* Microwave-Assisted Fluorous Synthesis of 2-Aryl-Substituted 4-Thiazolidinone and 4-Thiazinanone Libraries. J Comb Chem 2008, 10, 303-312 (Designated by ACS as one of the most accessed papers in 2008. IF 3.40).

10)Zhou HY, Wu SH, Zhai SM, Liu AF, Sun Y, Li RS, Zhang Y, Ekins S, Swaan PW, Fang B, Zhang B, Yan B.* Design, Synthesis, Cytoselective Toxicity, Structure-Activity Relationships, and Pharmacophore of Thiazolidinone Derivatives Targeting Drug-Resistant Lung Cancer Cells. J Med Chem 2008, 51, 1242-1251 (Highlighted by Drug Discovery Today, 13, 1107-1108, 2008. IF 5.48).

11)Zhou HY, Du FF, Li X, Zhang B, Li W, Yan B.* Characterization of Organic Molecules Attached to Gold Nanoparticle Surface Using High Resolution Magic Angle Spinning 1H NMR. J PhysChem C 2008, 112, 19360-19366. (IF 4.83)

12)Zhou HY, Mu QX, Gao NN, Liu AF, Xing YH, Gao SL, Zhang Q, Qu GB, Chen YY, Liu G, Zhang B, Yan B.* A Nano-Combinatorial Library Strategy for the Discovery of Nanotubes with Reduced Protein-Binding, Cytotoxicity, and Immune Response. NanoLett 2008, 8, 859-865.(IF 13.592)


13)Fourches D, Pu D, Li LW, Zhou HY, Mu QX, Su GX, Yan B, Tropsha A*Computer-Aided Design of Carbon Nanotubes with the Desired Bioactivity and Safety Profiles. Nanotoxicology. 2016 1-10(IF 6.41)

14)Huang J, Qian WP, Wang LY, Wu H, Zhou HY, Wang Y.A, Chen HB, Yang L*, Mao H.* Functionalized milk protein coated magnetic nanoparticles for MRI-monitored targeted therapy of pancreatic cancer. Int. J. NanoMed. 2016 in press

15)Li SH, Zhai SM, Liu Y, Zhou HY, Wu JM, Jiao Q, Zhang B, Zhu H,* Yan B* Experimental Modulation and Computational Model of Nano-Hydrophobicity. Biomaterials 2015, 52, 312-317. (IF 8.31)

16)Mu Y, Liu Y, Li LW, Tian C, Zhou HY, Zhang Q*, Yan B* The Novel Tubulin Polymerization Inhibitor MHPT Exhibits Selective Anti-tumor Activity against Rhabdomyosarcoma in vitro and in vivo. PLOS One. 2015, 10, e0121806. (IF 3.23)

17)Liu Y, Li F, Wu L, Wang W, Zhu H, Zhang Q, Zhou HY, Yan B.* Improving Both Aqueous Solubility and Anti-Cancer Activity by Assessing Progressive Lead Optimization Libraries. Bioorg Med Chem Lett. 2015 25, 1971-1915. (IF 2.42)

18)Mu QX, Jiang GB, Cheng LX, Zhou HY, Fourches D, Tropsha A, Yan B.* Chemical Basis of Interactions Between Engineered Nanoparticles and Biological Systems. Chem. Rev. 2014,114, 7740–7781. (IF 45.66)

19)Li LW, Liu Y, Zhang Q, Zhou HY, Zhang Y, Yan B.* Revealing Microtubule Damage-Triggered Cancer Cell Survival by Turning Kinase Dyrk1B On and Off. ACS Chem. Biol. 2014, 9, 731–742. (IF 5.35)

20)Zhang CK,Zhai SM, Li XE, Zhang Q, Wu L, Liu Y, Jiang CJ, Zhou HY, Li F, Zhang SS, Su GX, Zhang B, Yan B* Synergistic Action by Multi-targeting Compounds Produces a Potent Compound Combination for Human NSCLC both in vitro and in vivo. Cell Death & Disease 2014, 5, e1138. (IF 5.17)

21)Satpathy M, Zhou HY, Yang L.* Image-Guided Cancer Treatment Using Theranostic Nanoparticles. chapter in Yang XM., eds. Nanotechnology in Modern Medical Imaging & Interventions, Nova Science Publishers, Inc. U.S.A., 2013 187-212.

22)Zhang Q, Zhai SM, Li LW, Li XE, Zhou HY, Mu QX, Du YH, Yan B.* Anti-tumor selectivity of a novel Tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models, Biochem. Pharmacol. 2013,86, 351-360.(IF 4.65)

23)Zhang Q, Liu XJ, Li XE, Li CL, Zhou HY, Yan B.* Antitumor activity of (2E, 5Z)-5-(2-hydroxybenzylidene)-2-((4-phenoxyphenyl) imino) thiazolidin-4-one, a novel microtubule-depolymerizing agent, in U87MG human glioblastoma cells and corresponding mice xenograft model. J.Pharmacol. Sci. 2013, 122, 223-231.(IF 3.00)

24)Su GX, Zhou HY, Mu QX, Zhang Y, Li LW, Jiao PF, Jiang GB, Yan B.* Effective Surface Charge Density Determines the Electrostatic Attraction between Nanoparticles and Cells. J. Phys. Chem. C 2012, 116, 4993-4998. (IF 4.83)

25)Singh WM, Kudo S, Baine T, Zhou HY, DeYonker NJ, Pham TC, Bollinger JC, Baker DL, Yan B, Webster C E, Zhao X. Electrocatalytic and Photocatalytic Hydrogen Production in Aqueous Solution by a Molecular Pentacoordinated Cobalt Complex. Angew. Chem. Int. Ed. 2012, 51(24), 5941-5944. (IF 11.33)

26)Zhang Y, Mu QX, Zhou HY, Vrijens K, Roussel MF, Jiang GB, Yan B.* Binding of Carbon Nanotube to BMP Receptor Enhances Cell Differentiation and Inhibits Apoptosis via Regulating bHLH Transcription Factors, Cell Death and Disease 2012, 3, e308. (IF 5.17)

27)Jiao PF, Zhou HY, Otto M, Mu QX, Li LW, Su GX, Zhang Y, Butch E. R., Snyder S. E., Jiang GB, Yan B.* Leading Neuroblastoma Cells to Die by Multiple Premeditated Attacks from a MultifunctionalizedNanoconstruct. J Am ChemSoc 2011, 133, 13918-13921. (IF 11.44)

28)Li X, Zhou, HY, Yang L, Du GQ, Pai-Panandiker A, Yan B. Enhancement of Radiotherapy Effects in Vitro by Dual-Ligand Cancer Targeting Gold Naoparticles. Biomaterials. 2011, 32, 2540-2545. (IF 8.31)

29)Jiao P, Zhou HY, Chen LX, Yan B. Cancer-Targeting Multifunctionalized Gold Nanoparticles in Imaging and Therapy. Curr Med Chem. 2011, 18, 2086-2102(Designated by Bentham Science as one of the most accessed papers in June 2011. IF 3.71).

30)Li LW, Zhang Q,  Liu AF, Li, XE, Zhou HY, Liu Y, Yan B.* Proteome Interrogation Using Nanoprobes to Identify Targets of a Cancer-killing Molecule. J Am ChemSoc 2011, 133, 6886-6889. (IF 11.44)

31)Gao NN, Zhang, Q, Mu QX, Bai YH, Li LW, Zhou HY, Butch E. R., Powell T. B., Snyder S. E., Jiang GB, Yan B.* Steering Carbon Nanotubes to Scavenger Receptor Recognition by Nanotube Surface Chemistry Modification Partially Alleviates NFκB Activation and Reduces Its Immunotoxicity. ACS Nano, 2011, 5, 4581-4591. (IF 12.03)

32)Zhang Q, Zhou HY, Zhai SM, Yan B.* Natural Product-Inspired Synthesis of Thiazolidine and Thiazolidinone Compounds and Their Anticancer Activities. Curr Pharm Design 2010, 17, 1826-1842.(IF 3.28)

33)Liu AF, Zhou HY, Su GX, Zhang W, Yan B.* Fluorous Synthesis of 1,4-Benzodiazepine-2,5-dione Library. J Comb Chem 2009, 11, 1083-1093.(IF 3.40)

34)Qi MH, Zhou HY, Ma XF, Zhang B, Jefferies C, Yan B.* Feasibility of a Self-Calibrated LC/MS/UV Method to Determine the Absolute Amount of Compounds in Their Storage and Screening Lifecycle. J Comb Chem 2008, 10, 162-165.(IF 3.40)

35)Zhang B, Xing YH, Li ZW, Zhou HY, Mu QX, Yan B.* Functionalized Carbon Nanotubes Specifically Bind to Chymotrypsin Catalytic Site and Regulate its Enzymatic Function. NanoLett 2009, 9, 2280-2284. (IF 12.94)

36)Zhang Q, Feng W, Zhou HY, Yan B.* Advances in Preclinical Small Molecules for the Treatment of Non-Small Cell Lung Cancer. Expert OpinTher Pat 2009, 19, 731-751.(IF 3.44)

37)Mu, QX, Liu, W, Xing, YH, Zhou, HY, Li, ZW, Zhang, Y, Ji, LH, Wang, F, Si, ZK, Zhang, B, Yan, B.* Protein binding by functionalized multiwalled carbon nanotubes is governed by the surface chemistry of both parties and the nanotube diameter. J PhysChem C 2008, 112, 3300-3307. (IF 4.83)

38)Liu SJ, Ma ML, Zhou HY, Li Y, Han L. (E)-2-(hydroxyimino)-N-phenylacetamide. ActaCrystallographica Section E-Structure Reports Online 2006, 62, O316-O317. 

39)Hu QP, Li Y, Zhou HY, Zheng XF, Ma ML. 5-Formyl-2-methoxyphenyl 2-iodobenzoate. ActaCrystallographica Section E-Structure Reports Online 2006, 62, O109-O110.

40)Hu QP, Ma ML, Shi JX, Li Y, Zhou HY. (2RS,3RS)-2,3-Dimethyl-1,4-bis(3,4,5-trimethoxyphenyl) butane-1,4-dione. ActaCrystallographica Section E-Structure Reports Online 2004, 60, O2101-O2102.


授权专利:


1.一种抗肺癌的药物组合物。申请号:CN201010115656.X;公开公告号:CN101780074-A.      

2.噻唑烷酮衍生物及其在制备抗肿瘤药物中的应用。申请号:CN200810140397.9;公开公告号:CN101381348.     

3.表面化学基团修饰的碳纳米管化合物及其应用。申请号:CN200910020235.6;公开公告号:CN101503187.

4. 2-苯亚胺基-5-(4-二甲氨基苯亚甲基)-4-噻唑烷酮在制备抗乳腺癌药物中的应用。申请号:201210389642.6;申请日:2012年10月15日

5. 2-(4-羟基苯亚胺基)-5-(3-甲氧基-4-羟基苯亚甲基)-4-噻唑烷酮的制抗肿瘤药应用。申请号:201210439863.X;申请日:2012年11月6日

6. 一种噻唑烷酮衍生物在制备广谱抗癌药物中的应用。申请号:201310016506.7;申请日:2013年1月16日

7. 一种具有协同抗肿瘤作用的金纳米药物载体。申请号:201310128244.3;申请日:2013年4月12日


 真诚欢迎环境、化学和化学生物学感兴趣的高年级本科生、硕士生和博士生加入我们的研究团队!


 
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